Exemestane / Aromasin Maganin Ciwon daji na Anti Estrogen Steroids don Yanke / Zagayawa
Cikakken Bayani
Exemestane
Alade: Aromasin;Exemestan
Bayyanar: Fari ko Kusan Farin Lu'ulu'u Foda
Abun ciki na samfur: ≥ 99% CAS: 107868-30-4
Tsarin kwayoyin halitta: C20H24O2
Nauyin Kwayoyin Halitta: 296.40
Amfani: ana amfani da shi wajen maganin ciwon nono na metastatic.kuma ana amfani da shi azaman taimako wajen magance cutar sankarar nono da wuri.
Hakanan zaka iya jin ana kiranta Aromasin, wanda shine sanannen sunansa.Akwai wasu nau'ikan nau'ikan nau'ikan exemestane, waɗanda duk sun ƙunshi kashi ɗaya na miyagun ƙwayoyi.
Tukwici Na Sashi
Adadin Manya Na Yada Don Ciwon Kan Nono:
25 MG na baki sau ɗaya a rana
Sharhi:
- Ya kamata a yi amfani da wannan magani bayan cin abinci.
Amfani:
- Adjuvant lura da postmenopausal mata tare da estrogen-receptor tabbatacce farkon nono da suka samu shekaru biyu zuwa uku na tamoxifen kuma an canza zuwa exemestane don kammala jimlar shekaru biyar a jere na adjuvant hormonal far.
- Maganin ciwon daji na nono ga matan da suka shude wadanda cutar ta ci gaba bayan maganin tamoxifen.
Bayani
Aromasin (Exemestane acetate) yana ɗaya daga cikin abubuwan ban mamaki waɗanda ba wanda ya san ainihin abin da zai yi da su.Yana da ƙarni na uku Aromatase Inhibitor (AI) kamar Arimidex (Anastrozole) da Femera (Letrozole).
na uku ƙarni aromatase inhibitors, amfani da magani na metastatic nono ciwon daji da kuma amfani da matsayin taimako a cikin lura da farkon nono ciwon daji.
● Aromasin yana daya daga cikin abubuwan da ke hana isrogen karfi.
Aromasin yana daya daga cikin mafi kyawun mahadi don rage tasirin aromatizing na steroids.
● Aromasin yana samuwa ga masu gina jiki masu shan magungunan anabolic steroids.
● Aromasin kuma ana kiransa da Exemestane.
Yana aiki ta hanyar toshe enzyme aromatase, daga baya yana toshe samar da isrogen.
Aromasin kuma wani nau'in .antineoplastic (hormonal) albarkatun kasa ne.
Ana amfani da Aromasin don yaki da ciwon nono da kuma tayar da testosterone a jiki.
Exemestane yana toshe aiwatar da aromatisation.Don haka yana rage adadin isrogen a jiki.A farkon ciwon nono, shan exemestane na iya taimakawa wajen dakatar da ciwon nono dawowa.A cikin ci gaban kansar nono ƙwayoyin kansa na iya girma a hankali ko kuma su daina girma gaba ɗaya.
Exemestane shine mai hana aromatase.Wannan yana nufin yana toshe enzyme aromatase (wanda ake samu a cikin tsoka, fata, nono da kitsen jiki), wanda ake amfani dashi don canza androgens (hormones da glandan adrenal ke samarwa) zuwa estrogen.Idan babu estrogen, ciwace-ciwacen da ke dogara da wannan hormone don girma zai ragu
Amfanin Exemestane
>>.Gidan Jiki
Steroidal Exemestane inhibitor wanda ke aiki ta hanyar rage adadin isrogen da jiki ke samarwa.Yana aiki ta hanyar iyakance jujjuyawar Testosterone zuwa estrogen kuma matsakaicin adadin isrogen kashewa shine 85%.Har ila yau, miyagun ƙwayoyi yana rage matakan estradiol na kimanin 50%, da kuma ƙara yawan matakan testosterone.
Exemestane mai hanawa wanda ke aiki ta hanyar hana haɓakar isrogen.Yana da tasiri a haɓaka matakan Testosterone da IGF a cikin jiki.Har ila yau, miyagun ƙwayoyi yana da amfani sosai a lokacin tsarin maganin sake zagayowar lokacin da mutum ke ƙoƙarin mayar da matakan Testosterone na halitta don kauce wa hadarin sake zagayowar.
>>.Anti-estrogen magani
Da yake an gane shi a matsayin ɗaya daga cikin magunguna mafi tsada, Exemestane yana ɗaya daga cikin mafi aminci magungunan isrogen da 'yan wasa da masu gina jiki ke amfani da su.A likitance an ba da maganin musamman don maganin cutar kansar nono.Wanda aka fi sani da Selective Estrogen Receptor Modulator (SERM), an riga an yi amfani dashi don rigakafin gynocomastia.
Abubuwan da aka bayar na Exemestane
A)Exemestane don rigakafin ciwon nono:
Chemoprevention na ciwon nono wata dabara ce mai tasiri don rage yawan kamuwa da wannan cuta a cikin mata masu haɗari.Wakilan farko don nuna tasiri mai mahimmanci na chemopreventive sune SERMs tamoxifen da raloxifen.
Wani ingantaccen bincike mai zurfi na duk gwaje-gwajen rigakafin SERM ya nuna cewa suna iya rage yawan cutar sankarar nono a cikin mata masu girma da matsakaita, tasirin da ke dawwama ta hanyar raguwar cutar kansar nono mai ER.
B)Exemestane shine mai haɓaka steroidal na ƙarni na uku wanda ba zai iya jurewa ba na enzyme aromatase kuma yana da tasiri a cikin duk saitunan jiyya don ciwon nono, gami da chemoprevention.
A cikin saitin metastatic, an bincika exemestane sosai a matsayin layin farko, layi na biyu, da ƙarin jiyya kuma yanzu an yi rajista don kula da matan postmenopausal tare da ci gaba na hormone-receptor-positive nono cancer wanda cutar ta ci gaba bayan antiestrogen. far.
Na bayanin kula, yuwuwar rashin juriya tare da NSAI yana haifar da ƙarin dama a cikin jerin jiyya na wakilai na endocrine.Bugu da ƙari kuma, dangane da sakamako mai ma'ana na asibiti, exemestane tare da everolimus yana wakiltar wani zaɓi na warkewa mai tasiri don cutar da ta ci gaba bayan bayyanar NSAI.
Exemestane gabaɗaya yana jurewa da kyau, tare da bayanin martabar sakamako mai kama da na sauran AIs kuma gami da alamun menopausal, arthralgia, asarar kashi, da canza canjin lipid metabolism.
